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In the newborn period, hyperammonemia due to an inborn error of metabolism has a similar presentation to a number of acquired conditions, including sepsis, intracranial hemorrhage, congenital heart disease, and acute gastrointestinal events such as intussusception or volvulus

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These alterations can ultimately lead to both diastolic and systolic cardiac dysfunction, potentially resulting in heart failure (Moran et al., 2022)

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